In April of 2022, FDA approved Bristol Myers Squibb’s (BMS) Camzyos (mavacamten), the first treatment to target and inhibit cardiac myosin, the underlying protein involved in hypertrophic obstructive cardiomyopathy (HOCM), a rare disease that thickens and hardens the heart muscle wall—ultimately resulting in an obstruction of blood flow from the heart to the rest of the body. For patients, suffering with HOCM means battling shortness of breath, palpitations, and a drastically diminished quality of life, progressing toward life-threatening complications over time or via physical exertion. According to BMS’ website, it’s estimated that hypertrophic cardiomyopathy (HCM) impacts between one in 200 and one in 500 people, with HOCM being the most common type.
Here is an interview with Tom Garner, senior vice president, US cardiovascular and established brands, BMS:
A Heartfelt Solution: Camzyos (pharmexec.com)